Due to its high selectivity and sensitivity liquid chromatography-mass spectrometry (LC-MS) with quadrupole mass analysers are replacingtraditional UV detection in many bioanalytical laboratories.
ESI, APCI and APPI have become the ionization techniques of choice, covering a wide variety of analytes. The LC-MS methods are usually validated according to the FDA’s 2001 Guidance: Bioanalytical Method Validation.
Isotopically labeled (2H or 13C) internal standards have become very popular because they are capable of compensating for losses during sample preparation; LC separation; and differences in ionisation efficiencies or degree of ionisation often caused by co-elution of matrix constituents with the analyte.
LGC Standards as a key manufacturer of reference materials. We also distribute for leading compound producers and we can offer a wide range of compounds both labelled and unlabelled. To find the compound you are looking for, contact your local LGC Standards office. | 
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