AT-9283
Product Code
TRC-A790300
CAS Number
Product Format
Neat
Molecular Formula
C19 H23 N7 O2
Molecular Weight
381.43
Price and availability
Documentation
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Product Information
Product Notes
AT-9283 is a potent AuroraA, AuroraB, JAK3, JAK2 enzyme inhibitor in addition to being an Abl family & Bcr-Abl inhibitor. As a potent inhibitor of these kinases this small molecule has proven to inhibit growth and survival of cancer cells in vivo.
References [2] Santo L, et al. Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res. 2011 May 15; 17(10):3259-71. [3] Howard S, et al. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. Journal of Medicinal Chemistry (2009), 52(2), 379-388. [4] Kimura S. AT-9283, a small-molecule multi-targeted kinase inhibitor for the potential treatment of cancer. Current Opinion in Investigational Drugs (London, England : 2000). 2010 Dec; 11(12):1442-1449. |
Product Data
Analyte Name
AT-9283
CAS Number
896466-04-9
Molecular Formula
C19 H23 N7 O2
Molecular Weight
381.43
Accurate Mass
381.1913
SMILES
O=C(NC1CC1)Nc2c[nH]nc2c3nc4cc(CN5CCOCC5)ccc4[nH]3
InChI
InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
IUPAC
1-cyclopropyl-3-[3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]urea
Storage & Transport Information
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Attributes
Product Format
Neat
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