Product Code

TRC-A791780

CAS Number

125995-03-1

EP Description

Atorvastatin EP Impurity H

USP Description

Atorvastatin related compound H

Product Format

Neat

Molecular Formula

C33 H33 F N2 O4

Molecular Weight

540.62

API Family

Atorvastatin Calcium

Product Categories

Enzyme inhibitors, TRC, Impurity Reference Materials , Enzyme inhibitors, Kinase Modulators

Product Type

Impurity, Metabolite, API

Purity

>95% (HPLC)

Price and availability

48-hour USA dispatch time

Freight restricted.

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Product Information

Chemical Data

Analyte Name

(4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone)

CAS Number

125995-03-1

Molecular Formula

C33 H33 F N2 O4

Molecular Weight

540.62

Accurate Mass

540.2424

SMILES

CC(C)c1c(C(=O)Nc2ccccc2)c(c3ccccc3)c(c4ccc(F)cc4)n1CC[C@@H]5C[C@@H](O)CC(=O)O5

InChI

InChI=1S/C33H33FN2O4/c1-21(2)31-30(33(39)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-27-19-26(37)20-28(38)40-27/h3-16,21,26-27,37H,17-20H2,1-2H3,(H,35,39)/t26-,27-/m1/s1

IUPAC

5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Impurity

Product Format

Neat

Impurity Type

Intermediate

API Family

Atorvastatin Calcium

Purity

>95% (HPLC)

Product Description

Atorvastatin Lactone (Atorvastatin EP Impurity H) is an intermediate of Atorvastatin, a inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation.

References: Boyd, R., et al.: J. Clin. Pharmacol., 40, 91, (2000), Bogman, K., et al.: Br. J. Pharmacol., 132, 1183 (2001), Backman, J., et al.: Clin. Pharmacol. Ther., 72, 685 (2002), Kalvass, J., et al.: Drug Metab. Dispos., 35, 455(2007),

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Atorvastatin Lactone

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