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Product Overview

产品代码

TRC-T788100

CAS登记号

71324-48-6

产品形式

Neat

分子式

C22 H22 F3 N O6

分子量

453.41

产品类型

TRC, API Reference Standards & Research Materials

产品类型

API

产品信息

Chemical Data

分析物名称

N-Trifluoroacetyliso Deacetylcolchicine

CAS登记号

71324-48-6

分子式

C22 H22 F3 N O6

分子量

453.41

精确质量测定

453.1399

SMILES

COC1=CC2=C(C=CC1=O)c3c(CC[C@@H]2NC(=O)C(F)(F)F)cc(OC)c(OC)c3OC

InChI

InChI=1S/C22H22F3NO6/c1-29-16-10-13-12(6-8-15(16)27)18-11(5-7-14(13)26-21(28)22(23,24)25)9-17(30-2)19(31-3)20(18)32-4/h6,8-10,14H,5,7H2,1-4H3,(H,26,28)/t14-/m0/s1

IUPAC

2,2,2-trifluoro-N-[(7S)-1,2,3,9-tetramethoxy-10-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

产品数据

存储温度

+4°C

运输温度

Room Temperature

原产国

CANADA

产品形式

Neat

Product Description

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

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