Name: Danusertib
Brand: TRC
SKU: TRC-D185070

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Product Overview

Produkt-Code

TRC-D185070

CAS-Nummer

827318-97-8

Produktformat

Neat

Molekularformel

C26 H30 N6 O3

Molekulargewicht

474.55

API-Familie

Danusertib

Produktkategorien

TRC, Enzyme inhibitors, Enzyme inhibitors, API Reference Standards & Research Materials, Kinase Modulators, Kinase Inhibitors, Chiral catalysts, ligands, & reagents

Produkttyp

Synthesis Tools, API

Produktinformationen

An Aurora kinase inhibitor in the Abl family & Bcr-Abl inhibitors, used to treat patients with chronic myeloid leukemia. Danusertib in a phase II study of patients with advanced or metastatic breast, ovarian, colorectal, pancreatic, small-cell and non-small-cell lung cancers demonstrated marginal anti-tumour activity in common solid tumours after failure of prior systemic therapies.

References

[1] Fancelli, D., et al.: J. Med. Chem., 49, 7247 (2006).

[2] Carpinelli, P., et al.: Mol. Canc. Ther., 6, 3158 (2007).

[3] Coumar, M., et al.: J. Med. Chem., 52, 1050 (2009).

[4] Schöffski, P., Besse, B., Gauler, T., de Jonge, M.J.A., Scambia, G., Santoro, A., Davite, C., Jannuzzo, M.G., Petroccione, A. and Delord, J.-P. 'Efficacy and safety of biweekly i.v. administrations of the Aurora kinase inhibitor danusertib hydrochloride in independent cohorts of patients with advanced or metastatic breast, ovarian, colorectal, pancreatic, small-cell and non-small-cell lung cancer: a multi-tumour, multi-institutional phase II study', Annals of Oncology, 26(3), pp. 598-607 (2015).

Analytenname

Danusertib

CAS-Nummer

827318-97-8

Molekularformel

C26 H30 N6 O3

Molekulargewicht

474.55

Genaue Masse

474.2379

SMILES

CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N4CCN(C)CC4)c2C1)c5ccccc5

InChI

InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1

IUPAC

N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide

Lagertemperatur

+4°C

Versandtemperatur

Room Temperature

Herkunftsland

CANADA

Produkttyp

Synthesis Tools; API

Produktformat

Neat

API-Familie

Danusertib

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Chemical Data

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