Product Code

TRC-C640003

CAS Number

1217651-73-4

Product Format

Neat

Molecular Formula

C22 H19 D6 N O6

Molecular Weight

405.472

API Family

Colchicine

Product Categories

TRC, API Reference Standards & Research Materials, Apoptosis, Stable isotopes, Stable isotopes, Stable Isotope Labelled Analytical Standards, Cancer Research Chemicals and Analytical Standards, Pharmaceutical Toxicology Reference Materials

Product Type

Stable Isotope Labelled, API, Contaminant

Unlabelled CAS Number

64-86-8

Purity

>95% (HPLC)

Price and availability

48-hour USA dispatch time

Freight restricted.

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Product Information

Chemical Data

Analyte Name

Colchicine-d6

CAS Number

1217651-73-4

Molecular Formula

C22 H19 D6 N O6

Molecular Weight

405.472

Accurate Mass

405.2058

SMILES

[2H]C([2H])([2H])OC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C([2H])([2H])[2H]

InChI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3,2D3

IUPAC

2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Unlabelled CAS Number

64-86-8

SIL Type

Deuterium

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

API; Stable Isotope Labelled

Product Format

Neat

API Family

Colchicine

Purity

>95% (HPLC)

Product Description

An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

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Colchicine-d6

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