Product Code

TRC-H998025

CAS Number

693222-51-4

Product Format

Neat

Molecular Formula

C15 H13 N5 O2

Molecular Weight

295.30

API Family

Hymenialdisine

Product Categories

TRC, Enzyme inhibitors, Inhibits an enzyme, Impurity Reference Materials , Kinase Modulators

Price and availability

48-hour USA dispatch time

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Product Information

Chemical Data

Analyte Name

Hymenialdisine Analogue #1

CAS Number

693222-51-4

Molecular Formula

C15 H13 N5 O2

Molecular Weight

295.30

Accurate Mass

295.1069

SMILES

NC1=N\C(=C\2/CCNC(=O)c3[nH]c4ccccc4c23)\C(=O)N1

InChI

InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,18H,5-6H2,(H,17,21)(H3,16,19,20,22)/b11-8+

IUPAC

(5E)-5-(2-amino-5-oxo-1H-imidazol-4-ylidene)-2,3,4,10-tetrahydroazepino[3,4-b]indol-1-one

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

API Family

Hymenialdisine

Product Description

The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3+?, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymenialdisine.

References: Sharma, V., and Tepe, J.J.: Bioorg. & Medicinal Chem. Letters, 14, 4319 (2004), Sharma, V., et al.: J. Med. Chem., 47, 3700 (2004)

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