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Product Overview

Product Code

TRC-B592490

CAS Number

674289-55-5

Product Format

Neat

Molecular Formula

C18 H16 N2 O2

Molecular Weight

292.33

Product Categories

Enzyme inhibitors, TRC, Nitrogen compounds, Cytokine and Growth Factor Signalling Modulators, Additional Neuro Products, Building blocks, Neurology Research Chemicals and Analytical Standards, Cancer Research Chemicals and Analytical Standards, Chiral catalysts, ligands, & reagents

Product Type

Impurity, Synthesis Tools

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

(+/-)-Blebbistatin

CAS Number

674289-55-5

Molecular Formula

C18 H16 N2 O2

Molecular Weight

292.33

Accurate Mass

292.1212

SMILES

Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c4ccccc4

InChI

InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3

IUPAC

3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Purity

>95% (HPLC)

Product Description

Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100uM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II

References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)

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(+/-)-Blebbistatin

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