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Product Overview

Product Code

TRC-C643025

CAS Number

168555-66-6

Product Format

Neat

Molecular Formula

C18 H19 O8 P . 2 Na

Molecular Weight

440.29

Product Categories

Additional Neuro Products, TRC, Additional Covid-19 Research materials

Product Type

Bioactive Small Molecule

Documentation

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Product Information

Chemical Data

Analyte Name

Combretastatin A-4 Phosphate, Disodium Salt

CAS Number

168555-66-6

Molecular Formula

C18 H19 O8 P . 2 Na

Molecular Weight

440.29

Accurate Mass

440.0613

SMILES

[Na+].[Na+].COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1OP(=O)([O-])[O-]

InChI

InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;;

IUPAC

disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate

Product Data

Storage Temperature

+4°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Product Description

Phosphorylated Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

References: Hamel, E., et al.: Biochem. Pharmacol., 32, 3863 (1983), Chaplin, D.J., et al.: Br. J. Cancer, 74, S86, (1996)

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Combretastatin A4 Phosphate Disodium Salt

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