Product Code

TRC-D198900

CAS Number

3482-37-9

Product Format

Neat

Molecular Formula

C19 H21 N O5

Molecular Weight

343.37

API Family

Colchicine

Product Categories

TRC, Opiate and Opioid Reference Materials , Opiates, Apoptosis, Impurity Reference Materials

Product Type

Impurity, Metabolite

Price and availability

48-hour USA dispatch time

Freight restricted.

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Product Information

Chemical Data

Analyte Name

N-Deacetylcolchiceine

CAS Number

3482-37-9

Molecular Formula

C19 H21 N O5

Molecular Weight

343.37

Accurate Mass

343.142

SMILES

COc1cc2CC[C@H](N)C3=CC(=O)C(=CC=C3c2c(OC)c1OC)O

InChI

InChI=1S/C19H21NO5/c1-23-16-8-10-4-6-13(20)12-9-15(22)14(21)7-5-11(12)17(10)19(25-3)18(16)24-2/h5,7-9,13H,4,6,20H2,1-3H3,(H,21,22)/t13-/m0/s1

IUPAC

(7S)-7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Metabolite

Product Format

Neat

API Family

Colchicine

Product Description

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Tanaka, H., et al.: Canc. Res., 69, 6978 (2009), D'Elia, M., et al.: Chem. Biol., 16, 548 (2009),

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N-Deacetyl Colchiceine

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