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Product Overview

Product Code

TRC-C281105

CAS Number

163837-48-7

Product Format

Neat

Molecular Formula

C21 H25 Cl N2 O3 . 2 Cl H

Molecular Weight

461.81

API Family

Levocetirizine Dihydrochloride, Cetirizine

Product Categories

Pharmaceutical Reference Standards, TRC, API Reference Standards & Research Materials, Histamine receptors, Memory, Learning and Cognition, Schizophrenia, Sleep, Pain and Inflammation, Pharmaceutical Toxicology Reference Materials , Impurity Reference Materials

Product Type

Impurity, Metabolite, API

Alternate CAS Number

Free base: 130018-76-7

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

(S)-Cetirizine dihydrochloride

CAS Number

163837-48-7

Molecular Formula

C21 H25 Cl N2 O3 . 2 Cl H

Molecular Weight

461.81

Accurate Mass

460.1087

SMILES

Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@@H](c2ccccc2)c3ccc(Cl)cc3

InChI

InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m0../s1

IUPAC

2-[2-[4-[(S)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride

Alternate CAS Number

Free base: 130018-76-7

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Metabolite; Impurity; API

Product Format

Neat

API Family

Levocetirizine Dihydrochloride; Cetirizine

Purity

>95% (HPLC)

Product Description

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

References: De Vos, C., et al.: Ann. Allergy, 59, 278 (1987), Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987), Fadel, R., et al.: Clin. Allergy, 17, 373 (1987), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

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