Ion Channels for Cancer Therapy
Ion channels are transmembrane proteins that are important for the proliferation and response of immune cells attacking tumour cells. They facilitate the permeation of specific ions between intra- and extra-cellular environments and play a significant role in tumour cell functions, such as proliferation, migration, volume regulation, cell survival and apoptosis. Since these ion channels are important for the survival of cancer cells, they are referred as “oncogenic channels”.
Below you can see key pharmacological targets/channels expressed in different organs:
The role of various ion channels as promising pharmacological targets in oncology has been well-documented. Ion channel inhibition has the potential to reduce migration and invasion of cancer cells, as well as block tumour angiogenesis pathways, and although further work is needed to fully understand ion channel function in carcinogenesis and possible side effects, it is a focal area for current research.
Our extensive TRC catalogue provides the ideal compound collection for ion channel research, including inhibitors, activators, agonists, modulators, growth factors, selective antibodies, and related ELISA kits. We offer unique tools to help uncover the function of these oncogenic channels and elucidate their role in cancer.
Pharmacological roles of channel-targeted products:
If you would like to explore more, you can view our range here.