Cancer models, research chemicals and reference materials
From early stage drug discovery through to method development, drug substance testing and product release.
Cancer is a complex, multifactorial disease characterised by the unrestrained proliferation of cells which invade normal tissues and organs. Hanahan and Weinberg pioneered modern studies of cancer-related genetic aberrations and epigenetic changes in 2011, when they proposed 10 ‘Hallmarks’ for cancer research. These hallmarks include: evading growth suppressors, avoiding immune destruction, enabling replicative immortality, tumour-promoting inflammation, activating invasion and metastasis, inducing angiogenesis, genome instability and mutation, sustaining proliferative signalling and resisting cell apoptosis. Meanwhile, advances in genomics and biochemistry precipitated identification of key drug targets including cyclin-dependent kinases (CDK) and PARP enzymes, telomerases, p53, as well as RTK’s such as EGFR and VEGF.
Our extensive cancer portfolio can help from target identification to drug development and generics manufacturing. We provide industry-leading life science tools - from biologically active small molecules to cellular models, such as classical cancer cell lines and 3D screening platforms for the development of personalised medicines. We also supply API and impurity research chemicals as well as primary pharmaceutical reference standards to support your method development and drug batch release.