Product Code

TRC-A425000

CAS Number

134036-52-5

Product Format

Neat

Molecular Formula

C17 H14 N2 O3

Molecular Weight

294.30

Product Categories

TRC, Chiral catalysts, ligands, & reagents

Product Type

Synthesis Tools

Price and availability

48-hour USA dispatch time

Freight restricted.

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Product Information

Chemical Data

Analyte Name

AG-490

CAS Number

134036-52-5

Molecular Formula

C17 H14 N2 O3

Molecular Weight

294.30

Accurate Mass

294.1004

SMILES

Oc1ccc(\C=C(\C#N)/C(=O)NCc2ccccc2)cc1O

InChI

InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8-

IUPAC

(Z)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Product Description

A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

References: Stock, J., et al.: J. Biol. Chem., 267, 19753

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