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Product Overview

Product Code

TRC-D292045

CAS Number

404844-02-6

EP Description

Imatinib EP Impurity C

Product Format

Neat

Molecular Formula

C28 H29 N7 O

Molecular Weight

479.58

API Family

Imatinib Mesylate, Imatinib

Product Categories

TRC, Impurity Reference Materials , Enzyme inhibitors, Kinase Modulators, Kinase Inhibitors, Cancer Research Chemicals and Analytical Standards

Product Type

Impurity, Metabolite

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

N-Desmethyl Imatinib

CAS Number

404844-02-6

Molecular Formula

C28 H29 N7 O

Molecular Weight

479.58

Accurate Mass

479.2434

SMILES

Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc4nccc(n4)c5cccnc5

InChI

InChI=1S/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34)

IUPAC

N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamide

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Metabolite; Impurity

Product Format

Neat

API Family

Imatinib Mesylate; Imatinib

Purity

>95% (HPLC)

Product Description

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

References: Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

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