Product Code

TRC-L101030

Product Format

Neat

Molecular Formula

C18 H28 N2 O7 S

Molecular Weight

416.489

Product Categories

Ubiquitin/Proteasome System, TRC, Huntington's

Alternate CAS Number

145451-98-5

Price and availability

48-hour USA dispatch time

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Product Information

Chemical Data

Analyte Name

(+)-Lactacystin Allyl Ester

Molecular Formula

C18 H28 N2 O7 S

Molecular Weight

416.489

Accurate Mass

416.162

SMILES

CC(C)[C@@H](O)C1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(=O)C)C(=O)OCC=C

InChI

InChI=1S/C18H28N2O7S/c1-6-7-27-16(25)12(19-11(5)21)8-28-17(26)18(13(22)9(2)3)14(23)10(4)15(24)20-18/h6,9-10,12-14,22-23H,1,7-8H2,2-5H3,(H,19,21)(H,20,24)/t10-,12+,13-,14+,18?/m1/s1

IUPAC

prop-2-enyl (2R)-2-acetamido-3-[(3S,4R)-3-hydroxy-2-[(1R)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoate

Alternate CAS Number

145451-98-5

Product Data

Storage Temperature

+4°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Product Description

The precursor to Lactacystin, a selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multicatalytic proteinase complex).

References: Fenteany, G., et al.: Science, 268, 726 (1995), Fenteany, G., et al.: Proc. Natl. Acad. Sci. USA, 91, 3358 (1994),

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(+)-Lactacystin Allyl Ester

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