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Product Overview

Product Code

TRC-N635800

CAS Number

152946-68-4

Product Format

Neat

Molecular Formula

C14 H12 N4 O S . 2 Cl H

Molecular Weight

357.26

Product Categories

TRC, Chiral catalysts, ligands, & reagents

Product Type

Synthesis Tools

Documentation

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Product Information

Chemical Data

Analyte Name

Nolatrexed Dihydrochloride

CAS Number

152946-68-4

Molecular Formula

C14 H12 N4 O S . 2 Cl H

Molecular Weight

357.26

Accurate Mass

356.0265

SMILES

Cl.Cl.Cc1ccc2N=C(N)NC(=O)c2c1Sc3ccncc3

InChI

InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H

IUPAC

2-amino-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one;dihydrochloride

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Product Description

Antifolate thymidylate synthase inhibitor. Antineoplastic.

References: Webber, S.E., et al.: J. Med. Chem., 36, 733 (1993), Rafi, I., et al.: Clin. Cancer Res., 1, 1275 (1995), Dash, A.K., et al.: J. Pharm. Sci., 85, 1123 (1996), Webber, S., et al.: Cancer Chemother. Pharmacol., 37, 509 (1996), Stuart, K., et al.: Cancer, 86, 410 (1999),

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