Product Code

TRC-S589960

Product Format

Neat

Molecular Formula

C22H20N2Na2O6

Molecular Weight

454.39

Product Categories

TRC, Chiral Molecules , Pharmaceutical Toxicology Reference Materials

Product Type

Bioactive Small Molecule

Alternate CAS Number

142677-15-4

Price and availability

48-hour USA dispatch time

Freight restricted.

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Product Information

Chemical Data

Analyte Name

Sodium (S)-2-(12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate

Molecular Formula

C22H20N2Na2O6

Molecular Weight

454.39

Accurate Mass

454.11

SMILES

CCC1=C2C(C(N3C2)=CC([C@](CC)(O)C(O[Na])=O)=C(CO)C3=O)=NC4=CC=C(O[Na])C=C41

InChI

InChI=1S/C22H22N2O6.2Na/c1-3-12-13-7-11(26)5-6-17(13)23-19-14(12)9-24-18(19)8-16(15(10-25)20(24)27)22(30,4-2)21(28)29;;/h5-8,25-26,30H,3-4,9-10H2,1-2H3,(H,28,29);;/q;2*+1/p-2/t22-;;/m0../s1

Alternate CAS Number

142677-15-4

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Product Description

The active metabolite of Irinotecan (carboxylate form). SN-38 lactone and carboxylate may be considered pharmacokinetically distinct agents.

References: Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000), Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2003), Ashley, G., et al.: J. Antibiot., 57, 224 (2004),

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SN-38 Carboxylate Disodium Salt

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