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Product Overview

Product Code

TRC-D292047

CAS Number

1185103-28-9

Product Format

Neat

Molecular Formula

C28 2H8 H21 N7 O

Molecular Weight

487.63

API Family

Imatinib, Imatinib Mesylate

Product Categories

Pharmaceutical Reference Standards, TRC, Enzyme inhibitors, Impurity Reference Materials , Kinase Modulators, Stable isotopes, Kinase Inhibitors, Stable isotopes, Stable Isotope Labelled Analytical Standards

Product Type

Stable Isotope Labelled, Impurity, Metabolite

Unlabelled CAS Number

404844-02-6

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

N-Desmethyl Imatinib piperazinyl-d8

CAS Number

1185103-28-9

Molecular Formula

C28 2H8 H21 N7 O

Molecular Weight

487.63

Accurate Mass

487.2936

SMILES

[2H]C1([2H])NC([2H])([2H])C([2H])([2H])N(Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)C1([2H])[2H]

InChI

InChI=1S/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34)/i13D2,14D2,15D2,16D2

IUPAC

N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)methyl]benzamide

Unlabelled CAS Number

404844-02-6

SIL Type

Deuterium

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Metabolite; Stable Isotope Labelled

Product Format

Neat

API Family

Imatinib; Imatinib Mesylate

Purity

>95% (HPLC)

Product Description

A deuterated metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

References: Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

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