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Product Overview

Product Code

TRC-G407002

CAS Number

1092942-83-0

Product Format

Neat

Molecular Formula

C29 2H8 H23 N7 O . C H4 O3 S

Molecular Weight

597.76

API Family

Imatinib

Product Categories

Pharmaceutical Reference Standards, TRC, Enzyme inhibitors, Enzyme inhibitors, Kinase Modulators, Stable isotopes, Kinase Inhibitors, Stable isotopes, Stable Isotope Labelled Analytical Standards, Pharmaceutical Toxicology Reference Materials

Product Type

Bioactive small molecule, Stable Isotope Labelled

Unlabelled CAS Number

220127-57-1

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

Imatinib piperazinyl-d8 Mesilate

CAS Number

1092942-83-0

Molecular Formula

C29 2H8 H23 N7 O . C H4 O3 S

Molecular Weight

597.76

Accurate Mass

597.2973

SMILES

[2H]C1([2H])N(C)C([2H])([2H])C([2H])([2H])N(Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)C1([2H])[2H].CS(=O)(=O)O

InChI

InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)/i14D2,15D2,16D2,17D2;

IUPAC

methanesulfonic acid;N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)methyl]benzamide

Unlabelled CAS Number

220127-57-1

SIL Type

Deuterium

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Stable Isotope Labelled

Product Format

Neat

API Family

Imatinib

Purity

>95% (HPLC)

Product Description

A deuterated tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

References: Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

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Gleevec-d8 Mesylate (Imatinib-d8 Mesylate)

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