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Product Overview

Product Code

TRC-L322752

CAS Number

1189987-23-2

Product Format

Neat

Molecular Formula

C12 D4 H5 F3 N2 O2

Molecular Weight

274.232

API Family

Leflunomide

Product Categories

Enzyme inhibitors, TRC, Enzyme inhibitors, API Reference Standards & Research Materials, Kinase Modulators, Stable isotopes, Additional Neuro Products, Stable isotopes, Stable Isotope Labelled Analytical Standards, Pharmaceutical Toxicology Reference Materials

Product Type

Stable Isotope Labelled, Metabolite, API, Contaminant

Unlabelled CAS Number

75706-12-6

Documentation

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Product Information

Chemical Data

Analyte Name

Leflunomide-d4

CAS Number

1189987-23-2

Molecular Formula

C12 D4 H5 F3 N2 O2

Molecular Weight

274.232

Accurate Mass

274.087

SMILES

[2H]c1c([2H])c(c([2H])c([2H])c1NC(=O)c2cnoc2C)C(F)(F)F

InChI

InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)/i2D,3D,4D,5D

IUPAC

5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

Unlabelled CAS Number

75706-12-6

SIL Type

Deuterium

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Stable Isotope Labelled; Metabolite; API

Product Format

Neat

API Family

Leflunomide

Product Description

An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.

References: Vrenken, T., et al.: J. Hepatol., 49, 799 (2008),

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