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Product Overview

Product Code

TRC-N490135

CAS Number

104206-65-7

Product Format

Neat

Molecular Formula

C14 H10 F3 N O5

Molecular Weight

329.23

API Family

Nitisinone

Product Categories

TRC, API Reference Standards & Research Materials, Enzyme inhibitors, Pharmaceutical Toxicology Reference Materials

Product Type

Impurity, API

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

Nitisinone

CAS Number

104206-65-7

Molecular Formula

C14 H10 F3 N O5

Molecular Weight

329.23

Accurate Mass

329.0511

SMILES

[O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F

InChI

InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2

IUPAC

2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

API

Product Format

Neat

API Family

Nitisinone

Purity

>95% (HPLC)

Product Description

Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.

References: Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

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