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Product Overview

Product Code

TRC-B592500

CAS Number

856925-71-8

Product Format

Neat

Molecular Formula

C18 H16 N2 O2

Molecular Weight

292.33

Product Categories

TRC, Chiral Molecules , Enzyme inhibitors, Bioactive small molecules, Cytokine and Growth Factor Signalling Modulators, Additional Neuro Products, Neurology Research Chemicals and Analytical Standards, Cancer Research Chemicals and Analytical Standards, Chiral catalysts, ligands, & reagents

Product Type

Synthesis Tools

Purity

>95% (HPLC)

Documentation

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Product Information

Chemical Data

Analyte Name

(S)-(-)-Blebbistatin

CAS Number

856925-71-8

Molecular Formula

C18 H16 N2 O2

Molecular Weight

292.33

Accurate Mass

292.1212

SMILES

Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c4ccccc4

InChI

InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1

IUPAC

(3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Format

Neat

Purity

>95% (HPLC)

Product Description

Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. Blebbistatin blocks both blebbing and cytokinesis at 50-100uM.[Blebbistatin:a]D= -103 (c= 1.21 CHCl3)(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneBlebbistatin is a selective inhibitor of nonmuscle myosin II

References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)

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