Product Code

TRC-D292000

CAS Number

6104-71-8

EP Description

Clozapine Impurity C

USP Description

Clozapine Impurity C

Product Format

Neat

Molecular Formula

C17 H17 Cl N4

Molecular Weight

312.80

API Family

Clozapine

Product Categories

TRC, Antipsychotics, Benzodiazepines Reference Materials , Agonist & antagonist analogues, Impurity Reference Materials , Acetylcholine Receptors, Neurotransmission, Memory, Learning and Cognition, Parkinson's, Schizophrenia, Pain and Inflammation

Product Type

Impurity, Metabolite

Purity

>95% (HPLC)

Price and availability

48-hour USA dispatch time

Freight restricted.

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Product Information

Chemical Data

Analyte Name

N-Desmethylclozapine

CAS Number

6104-71-8

Molecular Formula

C17 H17 Cl N4

Molecular Weight

312.80

Accurate Mass

312.1142

SMILES

Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4

InChI

InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2

IUPAC

3-chloro-6-piperazin-1-yl-11H-benzo[b][1,4]benzodiazepine

Product Data

Storage Temperature

-20°C

Shipping Temperature

Room Temperature

Country of Origin

CANADA

Product Type

Metabolite

Product Format

Neat

API Family

Clozapine

Purity

>95% (HPLC)

Product Description

N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation.

References: Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)

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