Danusertib
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- structure.search.product.name Danusertib
- Product Code: TRC-D185070
- CAS Number: 827318-97-8
- Brand: TRC
Product Overview
Product Code
TRC-D185070
CAS Number
Product Format
Neat
Molecular Formula
C26 H30 N6 O3
Molecular Weight
474.55
API Family
DanusertibProduct Information
Product Notes
An Aurora kinase inhibitor in the Abl family & Bcr-Abl inhibitors, used to treat patients with chronic myeloid leukemia. Danusertib in a phase II study of patients with advanced or metastatic breast, ovarian, colorectal, pancreatic, small-cell and non-small-cell lung cancers demonstrated marginal anti-tumour activity in common solid tumours after failure of prior systemic therapies.
References [1] Fancelli, D., et al.: J. Med. Chem., 49, 7247 (2006). [2] Carpinelli, P., et al.: Mol. Canc. Ther., 6, 3158 (2007). [3] Coumar, M., et al.: J. Med. Chem., 52, 1050 (2009). [4] Schöffski, P., Besse, B., Gauler, T., de Jonge, M.J.A., Scambia, G., Santoro, A., Davite, C., Jannuzzo, M.G., Petroccione, A. and Delord, J.-P. 'Efficacy and safety of biweekly i.v. administrations of the Aurora kinase inhibitor danusertib hydrochloride in independent cohorts of patients with advanced or metastatic breast, ovarian, colorectal, pancreatic, small-cell and non-small-cell lung cancer: a multi-tumour, multi-institutional phase II study', Annals of Oncology, 26(3), pp. 598-607 (2015). |
Chemical Data
Analyte Name
Danusertib
CAS Number
827318-97-8
Molecular Formula
C26 H30 N6 O3
Molecular Weight
474.55
Accurate Mass
474.2379
SMILES
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N4CCN(C)CC4)c2C1)c5ccccc5
InChI
InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1
IUPAC
N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
Product Data
Storage Temperature
+4°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Synthesis Tools; API
Product Format
Neat
API Family
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