N,N’-Diacetyl-L-cystine, 90%
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Product Overview
Product Code
TRC-D312500
CAS Number
EP Description
Acetylcysteine EP Impurity C
USP Description
Acetylcysteine USP Impurity C
Product Format
Neat
Molecular Formula
C10 H16 N2 O6 S2
Molecular Weight
324.37
API Family
AcetylcysteineProduct Categories
TRC, Amino acid metabolites, Modified amino acids, Bioactive small molecules, Additional Covid-19 Research materials, Impurity Reference Materials
Product Type
ImpurityPurity
>95% (HPLC)
Documentation
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Product Information
Chemical Data
Analyte Name
N,N'-Diacetyl-L-cystine
CAS Number
5545-17-5
Molecular Formula
C10 H16 N2 O6 S2
Molecular Weight
324.37
Accurate Mass
324.045
SMILES
CC(=O)N[C@@H](CSSC[C@H](NC(=O)C)C(=O)O)C(=O)O
InChI
InChI=1S/C10H16N2O6S2/c1-5(13)11-7(9(15)16)3-19-20-4-8(10(17)18)12-6(2)14/h7-8H,3-4H2,1-2H3,(H,11,13)(H,12,14)(H,15,16)(H,17,18)/t7-,8-/m0/s1
IUPAC
(2R)-2-acetamido-3-[[(2R)-2-acetamido-2-carboxyethyl]disulfanyl]propanoic acid
Product Data
Storage Temperature
+4°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Impurity
Product Format
Neat
API Family
Purity
>95% (HPLC)
Product Description
N,N’-Diacetyl-L-cystine (DiNAC) is a disulfide dimer of N-acetylcysteine with immunomodulatory properties. Its intact disulfide bridge has been shown to be important for its ability to modify contact sensitivity/delayed hypersensitivity reactions in mice.1,2 At 3 uM/kg/day, DiNAC also demonstrates anti-atherosclerotic effects, improving endothelial function in Watanabe heritable hyperlipidemic rabbits. Acetylcysteine EP Impurity C.
References: Pettersson, K.,et al.:The antiatherogenic effect of DiNAC: Experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases. Cardiovascular Drug Reviews 21, 119 (2003); Wågberg, M., et al.: N,N'-Diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: Evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. Journal of Pharmacology and Experimental Therapeutics 299, 76 (2001)
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