Colchicine Methanethiosulfonate
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- structure.search.product.name Colchicine Methanethiosulfonate
- Product Code: TRC-C640030-5MG
- CAS Number: 1217821-52-7
- Brand: TRC
Product Overview
Product Code
TRC-C640030-5MG
CAS Number
Product Format
Neat
Molecular Formula
C22 H25 N O6 . C H4 O2 S2
Molecular Weight
511.61
Product Categories
TRC, Anticancerous, Apoptosis, Additional Covid-19 Research materials, API Reference Standards & Research Materials
Product Type
APIDocumentation
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Product Information
Chemical Data
Analyte Name
Colchicine Methanethiosulfonate
CAS Number
1217821-52-7
Molecular Formula
C22 H25 N O6 . C H4 O2 S2
Molecular Weight
511.61
Accurate Mass
511.1335
SMILES
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C.CS(=O)(=O)S
InChI
InChI=1S/C22H25NO6.CH4O2S2/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16;1-5(2,3)4/h7,9-11,16H,6,8H2,1-5H3,(H,23,24);1H3,(H,2,3,4)/t16-;/m0./s1
IUPAC
sulfanylsulfonylmethane;N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
API
Product Format
Neat
Product Description
The methanethiosulfonate derfivative of Colchicine (C640000), an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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