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Mikromol featured product: Diclofenac

Diclofenac structure

 

Featured product 

Diclofenac 

API and impurity reference standards

 

Introduction

 

Diclofenac (sold under the brand names Voltaren, Solaraze, Cambia and Lofena, among many others) is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory properties. It is commercially available as tablets, capsules, dragees, suppositories, gels, patches, eye drops, and as a solution of injection. Diclofenac is used in the management of pain, various inflammatory conditions , and dysmenorrhea (menstrual cramps).

 

Diclofenac was patented in 1965, and first introduced in Switzerland in 1973, before coming into medical use in the United States in 1988. Also available as a generic medication, it was the US’s 72nd most commonly prescribed medicine in 2020, with over nine million prescriptions. Diclofenac sodium was initially developed with the goal of improving the safety profile of diclofenac and providing convenient, once-daily dosing for the treatment of chronic pain. New drug products, using diclofenac potassium salt, are associated with faster absorption and rapid pain relief. These include diclofenac potassium immediate-release tablets, liquid-filled soft gel capsules, and powder for oral solution.

 

Mechanism of action

 

Diclofenac acts through the inhibition of the enzyme cyclooxygenase (COX-1 and -2) and the reduced synthesis of prostaglandins (PGs). PGs have broad activity in inflammation and pain signalling, and are  involved in modulation of nociception – mediating acute inflammation via their IP and EP2 receptors. By limiting the production of these PGs at the site of injury, diclofenac can reduce inflammation and pain. In addition, PGE2 can cross the blood-brain barrier and act on receptors on thermoregulatory neurons - triggering an increase in heat generation and reduction in heat loss, and resulting in a fever. By inhibiting PGE2 generation, diclofenac can reduce the activity of these neurons. Diclofenac has a short half-life of one to three hours and is therefore also administered in sustained-release forms.

 

Why not browse our range of diclofenac API and impurity reference standards below?

 

Diclofenac Sodium

Diclofenac Sodium

                        MM0006.00

 

Imp. A (EP): 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one

Imp. A (EP): 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one

MM0006.01 & MM0006.01-0025

 

Imp. B (EP): 2-[(2,6-Dichlorophenyl)amino]benzaldehyde

Imp. B (EP) 2-[(2,6-Dichlorophenyl)amino]benzaldehyde

MM0006.03 & MM0006.03-0025

Imp. C (EP): [2-[(2,6-Dichlorophenyl)amino]phenyl]methanol

 

Imp. C (EP) [2-[(2,6-Dichlorophenyl)amino]phenyl]methanol

MM0006.04 & MM0006.04-0025

Imp. D (EP): 2-[2-[(2-Bromo-6-chlorophenyl)amino]phenyl]acetic Acid

Imp. D (EP) 2-[2-[(2-Bromo-6-chlorophenyl)amino]phenyl]acetic Acid

 

MM0006.09 & MM0006.09-0025

Imp. D (EP) as Sodium Salt: Sodium 2-[2-[(2-Bromo-6-chlorophenyl)amino]phenyl]acetate

Imp. D (EP) as Sodium Salt Sodium 2-[2-[(2-Bromo-6-chlorophenyl)amino]phenyl]acetate

MM0006.05 & MM0006.05-0025

 

 

Imp. E (EP): 1,3-Dihydro-2H-indol-2-one

Imp. E (EP) 1,3-Dihydro-2H-indol-2-one

MM0006.02 & MM0006.02-0025

Imp. F (EP): N-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)acetamide

Imp. F (EP) N-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)acetamide

MM0006.36 & MM0006.36-0025

 

 

 

1-(2-Bromo-6-chlorophenyl)indolin-2-one

1-(2-Bromo-6-chlorophenyl)indolin-2-one

MM0006.06 & MM0006.06-0025

 

 

Methyl 2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetate (Methyl Ester of Diclofenac)

Methyl 2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetate (Methyl Ester of Diclofenac)

MM0006.10 & MM0006.10-0025

Ethyl 2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetate (Ethyl Ester of Diclofenac)

Ethyl 2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetate (Ethyl Ester of Diclofenac)

MM0006.11 & MM0006.11-0025

 

2-(2,6-Dichlorophenylamino)benzoic Acid

2-(2,6-Dichlorophenylamino)benzoic Acid

MM0006.12 & MM0006.12-0025

 

 

 

2,6-Dichlorodiphenylamine

2,6-Dichlorodiphenylamine

MM0006.15 & MM0006.15-0025

 

 

2-Bromo-6-chlorodiphenylamine

2-Bromo-6-chlorodiphenylamine

MM0006.16-0025

 

1-(2,6-Dichlorophenyl)indolin-2,3-dione

1-(2,6-Dichlorophenyl)indolin-2,3-dione

                        MM0006.17

 

Diclofenac Potassium

Diclofenac Potassium

MM0006.18

 

 

2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide

2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide

MM0006.19 & MM0006.19.0025

 

2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetic Acid (Diclofenac)

2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetic Acid (Diclofenac)

MM0006.20-0250

 

 


 

2,6-Dichloroaniline

2,6-Dichloroaniline

MM0006.21 & MM0006.21-0025

 

 

2-Bromo-6-chloroaniline

2-Bromo-6-chloroaniline

MM0006.22 & MM0006.22-0025

 

4'-Hydroxydiclofenac

4'-Hydroxydiclofenac

MM0006.23-0025

 

Dimethylammonium Diclofenac

Dimethylammonium Diclofenac

MM0006.25

 

N-Acetyl-N-phenyl-2,6-dichloroaniline

N-Acetyl-N-phenyl-2,6-dichloroaniline

MM0006.27 & MM0006.27-0025

 

 

Diethyl Phthalate

Diethyl Phthalate

MM0006.28

 

2'-Chloroacetanilide

2'-Chloroacetanilide

MM0006.31 & MM0006.31-0025

 

Bromobenzene

Bromobenzene

MM0006.32

Diclofenac 2,3-Butylene Glycol Ester

Diclofenac 2,3-Butylene Glycol Ester

MM0006.38

Diclofenac 1,2-Propylene Glycol Ester (Mixture of Isomers)

Diclofenac 1,2-Propylene Glycol Ester (Mixture of Isomers)

MM0006.39

Diclofenac Butylene Glycol Ester (Mixture of Isomers)

Diclofenac Butylene Glycol Ester (Mixture of Isomers)

MM0006.37

 

 

       

 

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