(+)-Lactacystin
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- structure.search.product.name (+)-Lactacystin
- Product Code: TRC-L101000
- CAS Number: 133343-34-7
- Brand: TRC
Product Overview
Product Code
TRC-L101000
CAS Number
Product Format
Neat
Molecular Formula
C15 H24 N2 O7 S
Molecular Weight
376.43
Documentation
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Product Information
Chemical Data
Analyte Name
(+)-Lactacystin
CAS Number
133343-34-7
Molecular Formula
C15 H24 N2 O7 S
Molecular Weight
376.43
Accurate Mass
376.1304
SMILES
CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(=O)C)C(=O)O
InChI
InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
IUPAC
(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Native/Parent; Bioactive Small Molecule
Product Format
Neat
Product Description
A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multicatalytic proteinase complex).
References: Fenteany, G., et al.: Science, 268, 726 (1995), Fenteany, G., et al.: Proc. Natl. Acad. Sci. USA, 91, 3358 (1994),
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