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Mikromol featured product: omeprazole

Mikromol feature omeprazole

 

Featured product

Omeprazole

API and impurity reference standards

 

Introduction

 

Omeprazole (also known as Losec, Prilosec, Losec MUPS, and Pyrocalm) is a medicine used to treat indigestion, heartburn and acid reflux. It also treats peptic ulcer disease, upper gastrointestinal bleeding, and Zollinger-Ellison syndrome - a disease in which tumours cause acid overproduction in the stomach. The medicine is taken as a capsule, tablet or suspension, or by injection into a vein, and is available both over the counter and on prescription. In 1988, omeprazole became the first of a class of compounds developed in 1960s Sweden and known as proton pump inhibitors (PPIs) to pass clinical trials. It is a powerful inhibitor, with relatively few and mild side effects (such as headaches, diarrhoea and stomach pain). Due to their good safety profile, several PPIs are available over the counter without a prescription, and they are widely used in North America. Astra Zeneca was the first company to release omeprazole and, when its patent ran out in 2001, it produced a new drug, esomeprazole, sold under the brand name Nexium. Omeprazole is chiral, and a racemic mixture of the (R)- and (S)-enantiomer, while esomeprazole is purely the (S)-enantiomer. It is less easily metabolised in the body - and so maintains a higher plasma drug concentration for longer, making it the more suitable choice of the two.

 

Mechanism of action

 

Proton pumps are membrane proteins responsible for building up proton gradients across a biological membrane. The proton pump responsible for stomach acid production is ATP-driven, and known as the hydrogen/potassium adenosine triphosphate enzyme system (H+,K+-ATPase). Found in the secretory surface of acid-producing parietal cells, it transports H+ ions into the stomach in exchange for K+ ions. Omeprazole is able to bind to a thiol group on the H+,K+-ATPase, irreversibly inhibiting the secretion of acid. As enantiomers, both omeprazole and esomeprazole have the same  degradation impurities, including N-oxide and S-oxide compounds.

 

 

LGC Mikromol manufactures a number of high-quality API and impurity reference standards for both omeprazole and esomeprazole. We invite you to browse the table below to find out more about our range. 

 

Standard name

Product Code

Omeprazole

 

MM0095.00-0250

Omeprazole Sodium

 

MM3011.00

Omeprazole Sulphone

 

MM0095.05

Omeprazole Sulphone

 

MM0095.05-0025

Omeprazole Sulphone N-Oxide

 

MM0095.16

Omeprazole N-Oxide

 

MM0095.07

2-[(RS)-[(4-Chloro-3,5-dimethylpyridin-2-yl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole

 

MM0095.15-0025

2-[(RS)-[(4-Chloro-3,5-dimethylpyridin-2-yl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole

 

MM0095.15

9-Methoxy-1,3-dimethyl-12-thioxopyrido[1',2':3,4]imidazo[1,2-a]benzimidazol-2(12H)-one

 

MM0095.02

 

8-Methoxy-1,3-dimethyl-12-thioxopyrido[1',2':3,4]imidazo[1,2-a]benzimidazol-2(12H)-one

 

MM0095.01

2-[(RS)-[(3,5-Dimethylpyridin-2-yl)methyl]sulphinyl]-5-methoxy-1H-benzimidazole

 

MM0095.04-0025

2-[(RS)-[(3,5-Dimethylpyridin-2-yl)methyl]sulphinyl]-5-methoxy-1H-benzimidazole

 

MM0095.04

5-Methoxy-1H-benzimidazole-2-thiol

 

MM0095.03

5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphanyl]-1H-benzimidazole (Ufiprazole)

 

MM0095.06-0025

5-Methoxy-1H-benzimidazole-2-thiol

 

MM0095.03-0025

5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphanyl]-1H-benzimidazole (Ufiprazole)

 

MM0095.06

Esomeprazole Sodium

 

MM3373.00

Esomeprazole Magnesium Trihydrate

 

MM1036.00

 

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