Aloisine A RP107
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- structure.search.product.name Aloisine A RP107
- Product Code: TRC-A575450
- CAS Number: 496864-16-5
- Brand: TRC
Product Overview
Product Code
TRC-A575450
CAS Number
Product Format
Neat
Molecular Formula
C16 H17 N3 O
Molecular Weight
267.33
Product Categories
Enzyme inhibitors, TRC, Enzyme inhibitors, Kinase Modulators
Product Type
Bioactive Small MoleculeDocumentation
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Product Information
Chemical Data
Analyte Name
Aloisine A RP107
CAS Number
496864-16-5
Molecular Formula
C16 H17 N3 O
Molecular Weight
267.33
Accurate Mass
267.1372
SMILES
CCCCc1c([nH]c2nccnc12)c3ccc(O)cc3
InChI
InChI=1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
IUPAC
4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Bioactive Small Molecule
Product Format
Neat
Product Description
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).
References: Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003), Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2006), Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2008),
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